SYRA3 is committed to disseminate its results among the scientific community at large. This section is intended to publicise the works produced by the group members in relation to the Action topics.


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List of publications

Journal Articles

Donzelli M, äuer-Krisch E, Nemoz C, Brochard T, Oelfke U. Conformal image-guided microbeam radiation therapy at the ESRF biomedical beamline ID17. Medical Physics [Internet]. 2016;43(6):3157 - 3167.
Livingstone J, Stevenson AW, Butler DJ, äusermann D, Adam çois. Characterization of a synthetic single crystal diamond detector for dosimetry in spatially fractionated synchrotron x-ray fields. Medical Physics [Internet]. 2016;43(7):4283 - 4293.
Pouyatos B, Nemoz C, Chabrol T, Potez M, äuer E, Renaud L, et al.. Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas. Scientific Reports [Internet]. 2016;6:27250.
Grotzer MA, Schültke E, Bräuer-Krisch E, Laissue JA. Microbeam radiation therapy: Clinical perspectives. Phys Med. 2015;31(6):564-7.
Romanelli P, Fardone E, Bucci D, Battaglia G, Bräuer-Krisch E, Requardt H, et al.. Microradiosurgical cortical transections generated by synchrotron radiation. Phys Med. 2015;31(6):642-6.
Wright MD. Microbeam radiosurgery: An industrial perspective. Phys Med. 2015;31(6):601-6.
Bouchet A, Serduc R, Laissue JAlbert, Djonov V. Effects of microbeam radiation therapy on normal and tumoral blood vessels. Phys Med. 2015;31(6):634-41.
Jacquet M, Suortti P. Radiation therapy at compact Compton sources. Phys Med. 2015;31(6):596-600.
Asur R, Butterworth KT, Penagaricano JA, Prise KM, Griffin RJ. High dose bystander effects in spatially fractionated radiation therapy. Cancer Lett. 2015;356(1):52-7.
Bravin A, Olko P, Schültke E, Wilkens JJ. SYRA3 COST Action--Microbeam radiation therapy: Roots and prospects. Phys Med. 2015;31(6):561-3.
Asur R, Butterworth KT, Penagaricano JA, Prise KM, Griffin RJ. High dose bystander effects in spatially fractionated radiation therapy. Cancer LettersCancer Letters [Internet]. 2015;356(1):52 - 57.
Fernandez-Palomo C, Mothersill C, Bräuer-Krisch E, Laissue J, Seymour C, Schültke E. γ-H2AX as a marker for dose deposition in the brain of wistar rats after synchrotron microbeam radiation. PLoS One. 2015;10(3):e0119924.
Girst S, Marx C, Bräuer-Krisch E, Bravin A, Bartzsch S, Oelfke U, et al.. Improved normal tissue protection by proton and X-ray microchannels compared to homogeneous field irradiation. Phys Med. 2015;31(6):615-20.
Bräuer-Krisch E, Adam J-F, Alagoz E, Bartzsch S, Crosbie J, DeWagter C, et al.. Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT). Phys Med. 2015;31(6):568-83.
Fernandez-Palomo C, Bräuer-Krisch E, Laissue J, Vukmirovic D, Blattmann H, Seymour C, et al.. Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo. Phys Med. 2015;31(6):584-95.
Studer F, Serduc R, Pouyatos B, Chabrol T, Bräuer-Krisch E, Donzelli M, et al.. Synchrotron X-ray microbeams: A promising tool for drug-resistant epilepsy treatment. Phys Med. 2015;31(6):607-14.
Ceresa C, Bravin A, Cavaletti G, Pellei M, Santini C. The Combined Therapeutical Effect of Metal-Based Drugs and Radiation Therapy: the Present Status of Research. Curr Med Chem. 2014;.
Ceresa C, Nicolini G, Semperboni S, Requardt H, Le Duc G, Santini C, et al.. Synchrotron-based Photon Activation Therapy Effect on Cisplatin Pre-treated Human Glioma Stem Cells. Anticancer Res. 2014;34(10):5351-5.
Ceresa C, Nicolini G, Semperboni S, Requardt H, Santini C, Pellei M, et al.. In Vitro study of heavy metal-based anticancer complexes: Activity, neurotoxicity and photon activation therapy's effect. Official journal of the Italian neurological society. 2014;Supplement October.
Sporea D, Mihai L, Sporea A, Lixandru A, Bräuer-Krisch E. Investigation of UV optical fibers under synchrotron irradiation. Opt Express. 2014;22(25):31473-85.
Ceresa C, Nicolini G, Requardt H, Le Duc G, Cavaletti G, Bravin A. The effect of Photon Activation Therapy on cisplatin pre-treated human tumour cell lines: comparison with conventional X-ray irradiation. J Biol Regul Homeost Agents. 2013;27(2):477-85.


Stefan BARTZSCH, Univ. Heidelberg, Germany (on-going)
Pauline FOURNIER, Univ. Wollongong, Australia (on-going)
Mattia DONZELLI, Univ. Joseph Fourier, Grenoble, France (on-going)
Sara SEMPERBONI, Univ. Bicocca, Milan, Italy (on-going)
Marine POTEZ, University of Berne, Switzerland (on-going)
Felix JAEKEL, to be defined, (on-going)
Danielle ANDERSON, University of Alberta, Edmonton, Canada (on-going)
Veronica DEL GROSSO, ESRF, CNR Segrate, Italy (on-going)
Giacomo BARBONE, Max-Plank, Munich/LMU, Germany (on-going)
Paul GIMENEZ, Univ. Joseph Fourier, France
Christian FERNANDEZ-PALOMO, Univ. Mc Master, Hamilton, Canada
Layal OBEID, Univ. Joseph Fourier, France


Background literature

Type of Publication: Journal Article
Anderson D, Andrais B, Mirzayans R, Siegbahn EA, Fallone BG, Warkentin B. Comparison of two methods for measuring gamma-H2AX nuclear fluorescence as a marker of DNA damage in cultured human cells: applications for microbeam radiation therapy. JOURNAL OF INSTRUMENTATION. 2013;8.
Barnard S, Bouffler S, Rothkamm K. The shape of the radiation dose response for DNA double-strand break induction and repair. Genome Integr. 2013;4(1):1.
Bouchet A, Lemasson B, Christen T, Potez M, Rome C, Coquery N, et al.. Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain. Radiother Oncol. 2013;108(1):143-8.
Fernandez-Palomo C, Schültke E, Smith R, Bräuer-Krisch E, Laissue J, Schroll C, et al.. Bystander effects in tumor-free and tumor-bearing rat brains following irradiation by synchrotron X-rays. Int J Radiat Biol. 2013;89(6):445-53.
Laissue JA, Bartzsch S, Blattmann H, Bräuer-Krisch E, Bravin A, Dalléry D, et al.. Response of the rat spinal cord to X-ray microbeams. Radiother Oncol. 2013;106(1):106-11.
Manning G, Rothkamm K. Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy. Br J Radiol. 2013;86(1027):20130173.
Pouyatos B, Serduc R, Chipaux M, Chabrol T, Bräuer-Krisch E, Nemoz C, et al.. Synchrotron X-ray interlaced microbeams suppress paroxysmal oscillations in neuronal networks initiating generalized epilepsy. Neurobiol Dis. 2013;51:152-60.
Schültke E, Trippel M, Bräuer-Krisch E, Renier M, Bartzsch S, Requardt H, et al.. Pencilbeam irradiation technique for whole brain radiotherapy: technical and biological challenges in a small animal model. PLoS One. 2013;8(1):e54960.
Smith RW, Wang J, Schültke E, Seymour CB, Bräuer-Krisch E, Laissue JA, et al.. Proteomic changes in the rat brain induced by homogenous irradiation and by the bystander effect resulting from high energy synchrotron X-ray microbeams. Int J Radiat Biol. 2013;89(2):118-27.
Anderson D, E Siegbahn A, B Fallone G, Serduc R, Warkentin B. Evaluation of dose-volume metrics for microbeam radiation therapy dose distributions in head phantoms of various sizes using Monte Carlo simulations. Phys Med Biol. 2012;57(10):3223-48.
Bouchet A, Boumendjel A, Khalil E, Serduc R, Bräuer E, Siegbahn EAlbert, et al.. Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors. J Synchrotron Radiat. 2012;19(Pt 4):478-82.
Ceberg C, Jönsson B-A, Prezado Y, Pommer T, Nittby H, Englund E, et al.. Photon activation therapy of RG2 glioma carrying Fischer rats using stable thallium and monochromatic synchrotron radiation. Phys Med Biol. 2012;57(24):8377-91.
Grisold W, Cavaletti G, Windebank AJ. Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol. 2012;14 Suppl 4:iv45-54.
Laissue JA, Blattmann H, Siegbahn EA, Slatkin DN. A misprint in a description of microbeam irradiations of rats' heads. Vet Ophthalmol. 2012;15(3):210-1.
Laissue JA, Blattmann H, Slatkin DN. [Alban Köhler (1874-1947): Inventor of grid therapy]. Z Med Phys. 2012;22(2):90-9.
Martínez-Rovira I, Sempau J, Prezado Y. Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy. Med. Phys. 2012;39:2829 – 2838.
Martínez-Rovira I, Sempau J, Prezado Y. Development and commissioning of a Monte Carlo photon beam model for the forthcoming clinical trials in microbeam radiation therapy. Med. Phys. 2012;39:119 – 131.
Rothkamm K, Crosbie JC, Daley F, Bourne S, Barber PR, Vojnovic B, et al.. In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks. PLoS One. 2012;7(1):e29853.
Somaiah N, Yarnold J, Daley F, Pearson A, Gothard L, Rothkamm K, et al.. The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy. Clin Cancer Res. 2012;18(19):5479-88.
Ainsbury EA, Bakhanova E, Barquinero JF, Brai M, Chumak V, Correcher V, et al.. Review of retrospective dosimetry techniques for external ionising radiation exposures. Radiat Prot Dosimetry. 2011;147(4):573-92.
Cavaletti G, Alberti P, Marmiroli P. Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics. Lancet Oncol. 2011;12(12):1151-61.
Chua MLee Kiang, Somaiah N, Bourne S, Daley F, A'hern R, Nuta O, et al.. Inter-individual and inter-cell type variation in residual DNA damage after in vivo irradiation of human skin. Radiother Oncol. 2011;99(2):225-30.
Sabatasso S, Laissue JAlbert, Hlushchuk R, Graber W, Bravin A, Bräuer-Krisch E, et al.. Microbeam radiation-induced tissue damage depends on the stage of vascular maturation. Int J Radiat Oncol Biol Phys. 2011;80(5):1522-32.
Bouchet A, Lemasson B, Le Duc G, Maisin C, Bräuer-Krisch E, Siegbahn EAlbert, et al.. Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks. Int J Radiat Oncol Biol Phys. 2010;78(5):1503-12.
Bräuer-Krisch E, Serduc R, Siegbahn EA, Le Duc G, Prezado Y, Bravin A, et al.. Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue. Mutat Res. 2010;704(1-3):160-6.
Carozzi VA, Canta A, Oggioni N, Sala B, Chiorazzi A, Meregalli C, et al.. Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies. Exp Neurol. 2010;226(2):301-9.
Cavaletti G, Marmiroli P. Chemotherapy-induced peripheral neurotoxicity. Nat Rev Neurol. 2010;6(12):657-66.
Crosbie JC, Anderson RL, Rothkamm K, Restall CM, Cann L, Ruwanpura S, et al.. Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues. Int J Radiat Oncol Biol Phys. 2010;77(3):886-94.
Martínez-Rovira I, Sempau J, Fernández-Varea JM, Bravin A, Prezado Y. Monte Carlo dosimetry for forthcoming clinical trials in x-ray microbeam radiation therapy. Phys. Med. Biol. 2010;55:4375 – 4388.
Serduc R, Bräuer-Krisch E, Siegbahn EA, Bouchet A, Pouyatos B, Carron R, et al.. High-precision radiosurgical dose delivery by interlaced microbeam arrays of high-flux low-energy synchrotron X-rays. PLoS One. 2010;5(2):e9028.
van der Sanden B, Bräuer-Krisch E, Siegbahn EAlbert, Ricard C, Vial J-C, Laissue J. Tolerance of arteries to microplanar X-ray beams. Int J Radiat Oncol Biol Phys. 2010;77(5):1545-52.
Bräuer-Krisch E, Requardt H, Brochard T, Berruyer G, Renier M, Laissue JA, et al.. New technology enables high precision multislit collimators for microbeam radiation therapy. Rev Sci Instrum. 2009;80(7):074301.
Rothkamm K, Horn S. gamma-H2AX as protein biomarker for radiation exposure. Ann Ist Super Sanita. 2009;45(3):265-71.
Serduc R, Bräuer-Krisch E, Bouchet A, Renaud L, Brochard T, Bravin A, et al.. First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy. J Synchrotron Radiat. 2009;16(Pt 4):587-90.
Serduc R, Bouchet A, Bräuer-Krisch E, Laissue JA, Spiga J, Sarun S, et al.. Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose. Phys Med Biol. 2009;54(21):6711-24.
Slatkin DN, Blattmann H, Wagner HP, Glotzer MA, Laissue JA. Prospects for microbeam radiation therapy of brain tumours in children. Dev Med Child Neurol. 2009;51(2):163.
Burdak-Rothkamm S, Rothkamm K, Prise KM. ATM acts downstream of ATR in the DNA damage response signaling of bystander cells. Cancer Res. 2008;68(17):7059-65.
Regnard P, Le Duc G, Bräuer-Krisch E, Troprès I, Siegbahn EAlbert, Kusak A, et al.. Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. Phys Med Biol. 2008;53(4):861-78.
Schültke E, Juurlink BHJ, Ataelmannan K, Laissue J, Blattmann H, Bräuer-Krisch E, et al.. Memory and survival after microbeam radiation therapy. Eur J Radiol. 2008;68(3 Suppl):S142-6.
Serduc R, van de Looij Y, Francony G, Verdonck O, van der Sanden B, Laissue J, et al.. Characterization and quantification of cerebral edema induced by synchrotron x-ray microbeam radiation therapy. Phys Med Biol. 2008;53(5):1153-66.
Serduc R, Christen T, Laissue J, Farion R, Bouchet A, van der Sanden B, et al.. Brain tumor vessel response to synchrotron microbeam radiation therapy: a short-term in vivo study. Phys Med Biol. 2008;53(13):3609-22.
Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM. ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene. 2007;26(7):993-1002.
Laissue JA, Blattmann H, Wagner HP, Grotzer MA, Slatkin DN. Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae. Dev Med Child Neurol. 2007;49(8):577-81.
Smilowitz HM, Weissenberger J, Weis J, Brown JD, O'Neill RJ, Laissue JA. Orthotopic transplantation of v-src-expressing glioma cell lines into immunocompetent mice: establishment of a new transplantable in vivo model for malignant glioma. J Neurosurg. 2007;106(4):652-9.
Miura M, Blattmann H, Bräuer-Krisch E, Bravin A, Hanson AL, Nawrocky MM, et al.. Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams. Br J Radiol. 2006;79(937):71-5.
Serduc R, Vérant P, Vial J-C, Farion R, Rocas L, Rémy C, et al.. In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature. Int J Radiat Oncol Biol Phys. 2006;64(5):1519-27.
Smilowitz HM, Blattmann H, Bräuer-Krisch E, Bravin A, Di Michiel M, Gebbers J-O, et al.. Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas. J Neurooncol. 2006;78(2):135-43.
Bräuer-Krisch E, Requardt H, Régnard P, Corde S, Siegbahn E, LeDuc G, et al.. New irradiation geometry for microbeam radiation therapy. Phys Med Biol. 2005;50(13):3103-11.
Bräuer-Krisch E, Bravin A, Lerch M, Rosenfeld A, Stepanek J, Di Michiel M, et al.. MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility. Med Phys. 2003;30(4):583-9.
Rothkamm K, Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A. 2003;100(9):5057-62.
Rothkamm K, Krüger I, Thompson LH, Löbrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol. 2003;23(16):5706-15.
Rothkamm K, Löbrich M. Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorigenesis and cancer treatment (review). Int J Oncol. 2002;21(2):433-40.
Rothkamm K, Kühne M, Jeggo PA, Löbrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res. 2001;61(10):3886-93.
Schweizer PM, Spanne P, Di Michiel M, Jauch U, Blattmann H, Laissue JA. Tissue lesions caused by microplanar beams of synchrotron-generated X-rays in Drosophila melanogaster. Int J Radiat Biol. 2000;76(4):567-74.
Stepanek J, Blattmann H, Laissue JA, Lyubimova N, Di Michiel M, Slatkin DN. Physics study of microbeam radiation therapy with PSI-version of Monte Carlo code GEANT as a new computational tool. Med Phys. 2000;27(7):1664-75.
Thomlinson W, Berkvens P, Berruyer G, Bertrand B, Blattmann H, Bräuer-Krisch E, et al.. Research at the European Synchrotron Radiation Facility medical beamline. Cell Mol Biol (Noisy-le-grand). 2000;46(6):1053-63.
Laissue JA, Geiser G, Spanne PO, Dilmanian FA, Gebbers JO, Geiser M, et al.. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays. Int J Cancer. 1998;78(5):654-60.
Slatkin DN, Spanne P, Dilmanian FA, Gebbers JO, Laissue JA. Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler. Proc Natl Acad Sci U S A. 1995;92(19):8783-7.
Nelson AR. The state of the union: the AMA works. J Miss State Med Assoc. 1990;31(5):163-6.
Type of Publication: Conference Paper
Hanson AL, Slatkin DN, Laissue JA. Unidirectional x-ray microbeam radiosurgery of infantile neuraxial malignancies: estimations of tolerable valley doses. In: Kollias N, Choi B, Zeng H, Kang HWook, Knudsen BE, Wong BJ, et al. SPIE BiOSPhotonic Therapeutics and Diagnostics IX [Internet]. San Francisco, California, USA: SPIE; 2013.
Laissue JA, Blattmann H, Di Michiel M, Slatkin DN, Lyubimova N, Guzman R, et al.. Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology. In: H. Barber B, Roehrig H, Doty FP, Schirato RC, Morton EJ. International Symposium on Optical Science and TechnologyPenetrating Radiation Systems and Applications III [Internet]. San Diego, CA: SPIE; 2001.
Laissue JA, Lyubimova N, Wagner H-P, Archer DW, Slatkin DN, Di Michiel M, et al.. Microbeam radiation therapy. In: H. Barber B, Roehrig H. SPIE's International Symposium on Optical Science, Engineering, and InstrumentationMedical Applications of Penetrating Radiation [Internet]. Denver, CO: SPIE; 1999.